Journal · Caffeine

Caffeine half-life: why we say "not after 2 pm"

Caffeine feels like it wears off in a couple of hours. Your body tells a different story. Here is the maths behind our 2 pm rule.

In short

  • In healthy adults, caffeine's half-life is about 5 hours on average, but it ranges from about 2 to 10 hours between people.
  • So half of a 2 pm coffee can still be in your body at 7 pm, and a quarter at midnight.
  • In one study, 400 mg taken 6 hours before bed still cut sleep by about an hour.
  • Official guidance: up to 400 mg a day for most adults, and 200 mg a day in pregnancy. Count every source.

What caffeine actually does

From the moment you wake, a chemical called adenosine slowly builds up in the brain. The longer you are awake, the more there is. This build-up is called "sleep pressure", and it is one of the two main forces behind sleep. The other is your body clock.

Caffeine has a similar shape to adenosine and sits in the same receptors, blocking them. The adenosine is still there. Caffeine just stops the brain from reading it. When the caffeine clears, the built-up sleep pressure is still waiting.

What "half-life" means

Half-life is the time it takes your body to clear half of a substance. For caffeine in healthy adults it averages about 5 hours. The liver does most of the work, and the speed varies a lot:

  • Slower: pregnancy (especially later on), the contraceptive pill, some medicines, liver problems, and certain genes.
  • Faster: smoking roughly halves the half-life.

The maths, for a typical person

Take a 100 mg coffee at different times and assume a 5-hour half-life:

Coffee atLeft at 10 pmLeft at midnight
8 amabout 14 mgabout 11 mg
12 noonabout 25 mgabout 19 mg
2 pmabout 33 mgabout 25 mg
5 pmabout 50 mgabout 38 mg

For a slow metaboliser, with a half-life closer to 8 hours, a 5 pm coffee would still leave more than half at 10 pm.

What the research found

In a well-known study, adults took 400 mg of caffeine (roughly 3 to 4 mugs of filter coffee) at bedtime, 3 hours before, or 6 hours before. Even at 6 hours, sleep measured at home was about an hour shorter. Many people did not notice the change themselves.

How much is in what?

Typical amounts, based on UK Food Standards Agency figures. Real amounts vary by brand and brew.

Drink or foodCaffeine
Mug of filter coffeeabout 140 mg
Mug of instant coffeeabout 100 mg
Mug of teaabout 75 mg
Can of energy drink (250 ml)about 80 mg
Can of colaabout 40 mg
50 g bar of plain chocolateunder 25 mg
NOVR Morning, one serving75 mg
NOVR Social, one serving50 mg

How much is too much?

The European Food Safety Authority concluded that, for healthy adults, up to 400 mg a day from all sources raises no safety concerns, and single doses of up to 200 mg are fine. In pregnancy the NHS advises no more than 200 mg a day. Children and people sensitive to caffeine should have less. Supplements count towards the total, so add up coffee, tea, energy drinks and supplements together.

How we use this at NOVR

  • Morning (75 mg) is made to sit alongside your usual coffee, not replace it, so check your daily total. We say take it before 2 pm.
  • Social (50 mg) is the one planned exception for an evening out. We say take it at least 4 hours before bed, and not every night.
  • Night contains no caffeine.

A cut-off is a habit, not a law. If you are a slow metaboliser, or your sleep is easily disturbed, an earlier cut-off may suit you better.

Sources

  1. Drake C et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med 2013;9:1195–200. doi:10.5664/jcsm.3170
  2. EFSA NDA Panel. Scientific opinion on the safety of caffeine. EFSA Journal 2015;13(5):4102. doi:10.2903/j.efsa.2015.4102
  3. Institute of Medicine (US). Caffeine for the Sustainment of Mental Task Performance, Appendix B: Pharmacology of caffeine. National Academies Press, 2001.
  4. Food Standards Agency. Caffeine and pregnancy / high-caffeine drinks guidance. food.gov.uk
  5. NHS. Foods to avoid in pregnancy: caffeine. nhs.uk

This article is general education, not medical advice. Listing a study describes the research only. It is not a claim that NOVR has the same effect.

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